{"id":276227,"date":"2025-10-04T04:00:44","date_gmt":"2025-10-04T04:00:44","guid":{"rendered":"https:\/\/www.europesays.com\/us\/276227\/"},"modified":"2025-10-04T04:00:44","modified_gmt":"2025-10-04T04:00:44","slug":"iu-researchers-identify-genes-role-in-immune-cells-that-fuel-pancreatic-cancer","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/us\/276227\/","title":{"rendered":"IU researchers identify gene\u2019s role in immune cells that fuel pancreatic cancer"},"content":{"rendered":"<p>New research from the Indiana University School of Medicine shows that a gene known for fighting cancer can also help certain immune cells support tumor growth.<\/p>\n<p>The study, published in <a href=\"https:\/\/www.science.org\/doi\/10.1126\/sciadv.adx5495\" class=\"Link\" target=\"_blank\" rel=\"noopener\">Science Advances<\/a>, focused on M2-like macrophages\u2014immune cells that weaken the body\u2019s ability to fight cancer. Scientists found that when the gene serine\/threonine kinase 11 (STK11) is missing in these cells, they shift into a state that helps tumors grow.<\/p>\n<p>In a pancreatic cancer mouse model, tumors progressed faster when these immune cells lacked the gene.<\/p>\n<p>Researchers said the findings could lead to more effective treatments by targeting how immune cells behave inside tumors. Future studies will examine how the immune environment changes as cancer advances.<\/p>\n<p>The work was supported by the National Institutes of Health and conducted through the <a href=\"https:\/\/cancer.iu.edu\/\" class=\"Link\" target=\"_blank\" rel=\"noopener\">IU Melvin and Bren Simon Comprehensive Cancer Center<\/a>. Research was supported by funding from the National Institutes of Health.<\/p>\n","protected":false},"excerpt":{"rendered":"New research from the Indiana University School of Medicine shows that a gene known for fighting cancer can&hellip;\n","protected":false},"author":3,"featured_media":276228,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[26],"tags":[815,159,67,132,68],"class_list":{"0":"post-276227","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-genetics","8":"tag-genetics","9":"tag-science","10":"tag-united-states","11":"tag-unitedstates","12":"tag-us"},"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@us\/115313903133059863","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/posts\/276227","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/comments?post=276227"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/posts\/276227\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/media\/276228"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/media?parent=276227"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/categories?post=276227"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/tags?post=276227"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}