{"id":28368,"date":"2025-06-30T23:33:10","date_gmt":"2025-06-30T23:33:10","guid":{"rendered":"https:\/\/www.europesays.com\/us\/28368\/"},"modified":"2025-06-30T23:33:10","modified_gmt":"2025-06-30T23:33:10","slug":"scientists-find-possible-cure-for-diseases-that-impacts-10-million-americans-in-groundbreaking-study","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/us\/28368\/","title":{"rendered":"Scientists find possible cure for diseases that impacts 10 million Americans in groundbreaking study"},"content":{"rendered":"

Scientists believe they might have found a cure for\u00a0diabetes<\/a>\u00a0and other debilitating autoimmune diseases, a groundbreaking new study revealed.\u00a0<\/p>\n

Researchers at NYU Langone Health, the Chinese Academy of Sciences, and Zhejiang University looked at why the body’s defense mechanism goes haywire and turns against itself, leaving a trail of incurable, life-changing diseases in its wake.<\/p>\n

The study looked at the autoimmune disorders type 1 diabetes, multiple sclerosis (MS), a debilitating neurological condition that causes immobility, and hepatitis, which causes liver inflammation and damage.<\/p>\n

Together, these diseases affect more than about 10million Americans, and while they are all partially manageable with therapies and medications, they can cause permanent damage and lead to a premature death.\u00a0<\/p>\n

Many patients end up on a lifelong cocktail of potent drugs <\/a>that can reduce the worst of the symptoms but have unpleasant side-effects, such as swelling, weight gain and osteoporosis.\u00a0<\/p>\n

But new research suggests a type of treatment<\/a> \u2013 called LAG-3\/TCR Bispecific T cell Silencer or BiTS \u2013 could potentially stop all of these incurable disorders in their tracks by ‘resetting’ the immune system so it ceases its attacks on healthy tissue.<\/p>\n

Some experts predict it could be one of the biggest advances in treatment for decades.<\/p>\n

\"Scientists <\/p>\n

Scientists believe they might have found a cure for diabetes off the back of a groundbreaking new study<\/p>\n

Your browser does not support iframes.<\/p>\n

T-cells are a type of white blood cell that play a crucial role in the immune system, patrolling the body, including the bloodstream, to identify and destroy harmful cells and organisms.<\/p>\n

But sometimes they struggle to differentiate between healthy cells and those that cause illness or disease, leading the T-cells to mistakenly attack healthy tissue.<\/p>\n

However, if T-cells are exposed to a protein called chimeric antigen receptor (CAR), it can alter their DNA and change the way they attack the body.\u00a0<\/p>\n

Once a T-cell becomes a CAR T-cell, it’s reproduced in large numbers in the lab and injected a few weeks later back into the patient’s body.<\/p>\n

But treatments focused on T-cells have been elusive because blocking their action weakens the immune system and creates risk for infections and cancer.\u00a0<\/p>\n

CAR T-cell therapy can also have serious effects on the nervous system, leading to a condition known as immune effector cell-associated neurotoxicity syndrome (ICANS).\u00a0<\/p>\n

This can result in symptoms such as headaches, confusion, agitation, seizures\u00a0 and trouble speaking.<\/p>\n

However, the new research in mice published in the journal Cell, reveals how a newly-designed antibody could help shut down T-cells in a more effective way and prevent these harmful side effects.<\/p>\n

The study results are based on the presence of T-cell receptors (TCRs) and checkpoints.\u00a0<\/p>\n

TCRs are turned on by the body’s own proteins in autoimmune diseases.\u00a0<\/p>\n

Checkpoints like LAG-3 are also turned on by specific signaling partners, but when this occurs they suppress the T-cell’s activity.<\/p>\n

This means the T-cell’s ability to attack other cells, such as cancer cells, is reduced.\u00a0\u00a0<\/p>\n

By introducing the antibody, it helped to prevent T-cells from damaging the body, focused on regulating their activity and supported the body’s natural immune defenses.\u00a0<\/p>\n

This approach is being explored and used in the treatment of various autoimmune diseases.\u00a0<\/p>\n

In autoimmune models of hepatitis, the team’s BiTS treatment reduced T cell infiltration and liver damage.\u00a0<\/p>\n

They also treated mice prone to develop multiple sclerosis with short-term, preventive BiTS prior to the onset of disease symptoms, and they reported that BiTS-treated mice had reduced disease by a standard measure.\u00a0<\/p>\n

‘Our study… may foster more proximity-based, spatially-guided therapeutic designs like BiTS as immunotherapy for other human diseases,’ said co-first author Jia You, a research scientist in Dr. Wang’s lab.<\/p>\n

‘Our findings reveal an intricate mechanism that enables a careful treatment approach to T-cell driven autoimmune diseases, which currently lack effective immunotherapies,’ said co-senior study author Dr Jun Wang, assistant professor in the Department of Pathology at NYU Grossman School of Medicine.\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"Scientists believe they might have found a cure for\u00a0diabetes\u00a0and other debilitating autoimmune diseases, a groundbreaking new study revealed.\u00a0…\n","protected":false},"author":3,"featured_media":28369,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[211,210,67,132,68],"class_list":{"0":"post-28368","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-health","8":"tag-dailymail","9":"tag-health","10":"tag-united-states","11":"tag-unitedstates","12":"tag-us"},"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@us\/114774933845736381","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/posts\/28368","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/comments?post=28368"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/posts\/28368\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/media\/28369"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/media?parent=28368"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/categories?post=28368"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/tags?post=28368"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}