{"id":287028,"date":"2025-10-08T17:12:15","date_gmt":"2025-10-08T17:12:15","guid":{"rendered":"https:\/\/www.europesays.com\/us\/287028\/"},"modified":"2025-10-08T17:12:15","modified_gmt":"2025-10-08T17:12:15","slug":"scientists-just-reversed-alzheimers-in-mice-could-they-do-it-in-humans","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/us\/287028\/","title":{"rendered":"Scientists Just Reversed Alzheimer\u2019s in Mice. Could They Do It in Humans?"},"content":{"rendered":"

Scientists on Tuesday reported that they had reversed Alzheimer\u2019s disease<\/a> in mice, a feat that offers hope of a potential cure for the devastating form of dementia in humans.<\/p>\n

In a paper published Tuesday in Signal Transduction and Targeted Therapy<\/a>, a team of researchers describe how, by harnessing the brain\u2019s garbage disposal system, they managed to repair the brain and reverse the progress of the disease in the animals.<\/p>\n

Specifically, they used nanotechnology to target and restore the brain\u2019s \u201cvascular gatekeeper,\u201d the blood-brain barrier, which protects the brain from toxins and streamlines blood flow in and out of the brain.<\/p>\n

Maintenance work <\/p>\n

The new method came from studying how the buildup of \u201cwaste\u201d proteins such as amyloid-beta (A\u03b2) impairs neuron function. Sometimes, clever solutions to complex problems come from going back to the basics.<\/p>\n

Typically, the blood-brain barrier filters out unwanted substances from the brain, but in people with Alzheimer\u2019s, the barrier gets clogged or fails to respond properly to intruders.<\/p>\n

\u201cWe think it works like a cascade: when toxic species such as A\u03b2 accumulate, disease progresses,\u201d Giuseppe Battaglia, study senior author and a neuroscientist at the Institute for Bioengineering of Catalonia, said in a statement<\/a>.<\/p>\n

\u201cBut once the vasculature is able to function again,\u201d Battaglia said, \u201cit starts clearing A\u03b2 and other harmful molecules, allowing the whole system to recover its balance.\u201d<\/p>\n

How they did it <\/p>\n

Battaglia and his team developed nanoparticles that mimicked a protein called LRP1, a molecule typically responsible for reacting to toxins in the blood-brain barrier.<\/p>\n

For the study, the researchers genetically engineered mice to produce more amyloid-beta proteins and to show significant cognitive decline similar to Alzheimer\u2019s. Each mouse received three injections of the new drug, and the researchers observed changes in their behavior and brain activity for 6 months.<\/p>\n

The results were impressive. A 12-month-old mouse (equivalent to a 60 year-old human) that received treatment, when reassessed at 18 months (90 year-old human) old, had \u201crecovered the behavior of a healthy mouse,\u201d the scientists found.<\/p>\n

\u201cWhat\u2019s remarkable is that our nanoparticles act as a drug and seem to activate a feedback mechanism that brings this clearance pathway back to normal levels,\u201d Battaglia said. Surprisingly, the treatment took just three injections for it to reverse the progression of Alzheimer\u2019s in mice, the researchers reported.<\/p>\n

As with all mice studies, it will take much more work before this treatment could be tested for use in humans. But the results suggest that the approach, which essentially coaxes the brain to return to a healthy state, could hold promise for this incurable disease.<\/p>\n","protected":false},"excerpt":{"rendered":"Scientists on Tuesday reported that they had reversed Alzheimer\u2019s disease in mice, a feat that offers hope of…\n","protected":false},"author":3,"featured_media":287029,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[10263,4465,210,1184,67,132,68],"class_list":{"0":"post-287028","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-health","8":"tag-alzheimers-disease","9":"tag-brain","10":"tag-health","11":"tag-medicine","12":"tag-united-states","13":"tag-unitedstates","14":"tag-us"},"share_on_mastodon":{"url":"","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/posts\/287028","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/comments?post=287028"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/posts\/287028\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/media\/287029"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/media?parent=287028"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/categories?post=287028"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/tags?post=287028"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}