{"id":395122,"date":"2025-11-21T17:47:24","date_gmt":"2025-11-21T17:47:24","guid":{"rendered":"https:\/\/www.europesays.com\/us\/395122\/"},"modified":"2025-11-21T17:47:24","modified_gmt":"2025-11-21T17:47:24","slug":"ancient-killer-is-rapidly-becoming-resistant-to-antibiotics-scientists-warn-sciencealert","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/us\/395122\/","title":{"rendered":"Ancient Killer Is Rapidly Becoming Resistant to Antibiotics, Scientists Warn : ScienceAlert"},"content":{"rendered":"

Despite having plagued humans for millennia<\/a>, typhoid fever<\/a> is rarely considered a threat in developed countries today. But this ancient killer is still very much a danger in our modern world<\/a>.<\/p>\n

Research published in 2022<\/a> revealed the bacterium that causes typhoid fever is evolving extensive drug resistance, and is rapidly replacing strains that aren’t resistant.<\/p>\n

Currently, antibiotics are the only way to effectively treat typhoid, which is caused by the bacterium Salmonella enterica<\/a> serovar Typhi (S Typhi). Yet over the past three decades, the bacterium’s resistance to oral antibiotics has been growing and spreading.<\/p>\n

Related: Powerful New Antibiotic Was ‘Hiding in Plain Sight’ For Decades<\/a><\/strong><\/p>\n

In their study, scientists from multiple countries sequenced the genomes of 3,489 S Typhi strains contracted from 2014 to 2019 in Nepal, Bangladesh, Pakistan, and India, and found a rise in extensively drug-resistant (XDR) Typhi.<\/p>\n

Watch the video below for a summary of the study:<\/p>\n

\"YouTube frameborder=”0\u2033 allow=”accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share” referrerpolicy=”strict-origin-when-cross-origin” allowfullscreen><\/p>\n

XDR Typhi is not only impervious to frontline antibiotics, like ampicillin, chloramphenicol, and trimethoprim\/sulfamethoxazole, but it is also growing resistant<\/a> to newer antibiotics, like fluoroquinolones and third-generation cephalosporins.<\/p>\n

Even worse, these strains are spreading globally at a rapid rate.<\/p>\n

While most XDR Typhi cases stem from south Asia, researchers have identified nearly 200 instances of international spread since 1990.<\/p>\n

Most strains have been exported to Southeast Asia, as well as East and Southern Africa, but typhoid superbugs have also been found in the UK, the US, and Canada.<\/p>\n

“The speed at which highly resistant strains of S Typhi have emerged and spread in recent years is a real cause for concern, and highlights the need to urgently expand prevention measures, particularly in countries at greatest risk,” said<\/a> Stanford University infectious disease researcher Jason Andrews when the results were published.<\/p>\n

\"Subscribe<\/a><\/p>\n

Scientists have been warning about drug-resistant typhoid for years now. In 2016, the first XDR typhoid strain was identified in Pakistan<\/a>. By 2019, it had become the dominant genotype in the nation.<\/p>\n

Historically, most XDR typhoid strains have been fought with third-generation antimicrobials, like quinolones<\/a>, cephalosporins<\/a>, and macrolides<\/a>.<\/p>\n

But by the early 2000s, mutations that confer resistance to quinolones accounted for more than 85 percent of all cases in Bangladesh, India, Pakistan, Nepal, and Singapore. At the same time, cephalosporin resistance was also taking over.<\/p>\n

Today, only one oral antibiotic is left<\/a>: the macrolide, azithromycin<\/a>. And this medicine might not work for much longer.<\/p>\n

The 2022 study found<\/a> mutations that confer resistance to azithromycin are now also spreading, “threatening the efficacy of all oral antimicrobials for typhoid treatment”. While these mutations have not yet been adopted by XDR S Typhi, if they are, we are in serious trouble.<\/p>\n

If untreated, up to 20 percent of typhoid cases can be fatal, and in 2024, there were over 13 million cases of typhoid reported<\/a>.<\/p>\n

Future outbreaks can be prevented to some extent with typhoid conjugate vaccines<\/a>, but if access to these shots is not expanded globally, the world could soon have another health crisis<\/a> on its hands.<\/p>\n

\"AA world map highlighting regions where vaccination against typhoid is recommended. (CDC<\/a>)<\/p>\n

“The recent emergence of XDR and azithromycin-resistant S Typhi creates greater urgency for rapidly expanding prevention measures, including use of typhoid conjugate vaccines in typhoid-endemic countries,” the authors write<\/a>.<\/p>\n

“Such measures are needed in countries where antimicrobial resistance prevalence among S Typhi isolates is currently high, but given the propensity for international spread, should not be restricted to such settings.”<\/p>\n

Related: Tomato Juice Can Kill Salmonella, The Bacteria That Terrorizes Our Guts<\/a><\/strong><\/p>\n

South Asia might be the main hub for typhoid fever, accounting for 70 percent<\/a> of all cases, but if COVID-19<\/a> taught us anything, it is that disease variants<\/a> in our modern, globalized world are easily spread<\/a>.<\/p>\n

\"TyphoidTyphoid inoculation at a rural school, San Augustine County, Texas. April, 1943. (John Vachon\/United States Farm Security Administration\/Wikimedia Commons\/Public Domain<\/a>)<\/p>\n

To prevent that from happening, health experts argue nations must expand access to typhoid vaccines and invest in new antibiotic research<\/a>.<\/p>\n

A 2021 study<\/a> in India, for instance, estimated that if children are vaccinated against typhoid in urban areas, it could prevent up to 36 percent of typhoid cases and deaths.<\/p>\n

Pakistan is leading the way on this front. It was the first nation in the world to offer routine immunization for typhoid<\/a>. A small number of countries have now followed suit or are “planning or considering introduction<\/a>“.<\/p>\n

The World Health Organization<\/a> has prequalified four typhoid conjugate vaccines as of April 2025, according to the CDC<\/a>, which states “these vaccines are being introduced into childhood immunization programs in typhoid-endemic countries.”<\/p>\n

Antibiotic resistance is one of the world’s leading causes of death<\/a>, claiming the lives of more people than HIV<\/a>\/ AIDS<\/a> or malaria<\/a>. Where available, vaccines are<\/a> some of the best tools<\/a> we have to prevent future catastrophe<\/a>.<\/p>\n

We don’t have time to waste.<\/p>\n

The study was published in The Lancet Microbe<\/a>.<\/p>\n

An earlier version of this article was published in June 2022.<\/p>\n","protected":false},"excerpt":{"rendered":"Despite having plagued humans for millennia, typhoid fever is rarely considered a threat in developed countries today. But…\n","protected":false},"author":3,"featured_media":395123,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[210,352,67,132,68],"class_list":{"0":"post-395122","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-health","8":"tag-health","9":"tag-msft-content","10":"tag-united-states","11":"tag-unitedstates","12":"tag-us"},"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@us\/115588947203679537","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/posts\/395122","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/comments?post=395122"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/posts\/395122\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/media\/395123"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/media?parent=395122"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/categories?post=395122"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/tags?post=395122"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}