{"id":425292,"date":"2025-12-05T00:48:18","date_gmt":"2025-12-05T00:48:18","guid":{"rendered":"https:\/\/www.europesays.com\/us\/425292\/"},"modified":"2025-12-05T00:48:18","modified_gmt":"2025-12-05T00:48:18","slug":"breakthrough-blood-test-can-find-dementia-risk-before-symptoms-start","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/us\/425292\/","title":{"rendered":"&#8216;Breakthrough&#8217; blood test can find dementia risk before symptoms start"},"content":{"rendered":"<p>There\u2019s new progress in the battle against Alzheimer\u2019s disease.<\/p>\n<p><a href=\"https:\/\/www.alz.org\/alzheimers-dementia\/facts-figures\" target=\"_blank\" rel=\"noopener\">About 1 in 9 US seniors<\/a> has Alzheimer\u2019s, the most common form of dementia, which slowly impairs memory, thinking skills and the ability to perform even basic tasks.<\/p>\n<p>There is no single, easy test to diagnose Alzheimer\u2019s, but a <a href=\"https:\/\/jamanetwork.com\/journals\/jamaneurology\/article-abstract\/2842195\" target=\"_blank\" rel=\"noopener\">new review<\/a> of 18 scientific studies confirms that a simple blood test can detect early signs of the brain disorder before <a href=\"https:\/\/nypost.com\/2024\/12\/12\/health\/4-warning-signs-that-may-indicate-early-alzheimers-disease\/\" target=\"_blank\" rel=\"noopener\">cognitive symptoms<\/a> appear.<\/p>\n<p>Alzheimer\u2019s disease gradually destroys memory, thinking skills and the ability to perform even basic tasks. WavebreakMediaMicro \u2013 stock.adobe.com<\/p>\n<p>The protein p-tau217 has become a reliable Alzheimer\u2019s biomarker because its concentration in the blood is strongly linked to the presence of amyloid plaques and tau tangles in the brain, two hallmarks of Alzheimer\u2019s.<\/p>\n<p>The research out this week in JAMA Neurology supports the use of p-tau217 blood tests as a \u201cminimally invasive tool\u201d for early identification of Alzheimer\u2019s, \u201cparticularly in settings where timely intervention with disease-modifying therapies may offer the greatest benefit in slowing or preventing disease progression.\u201d<\/p>\n<p><a href=\"https:\/\/feinstein.northwell.edu\/institutes-researchers\/our-researchers\/liron-sinvani-md\" target=\"_blank\" rel=\"noopener\">Dr. Liron Sinvani<\/a>, director of the Geriatric Hospitalist\u00a0Service at Northwell Health and director of research for hospital medicine, called the finding \u201ca major breakthrough.\u201d<\/p>\n<p>\u201cJust a simple blood test to see if this protein,\u00a0this p-tau217, is present can\u00a0indicate\u00a0that someone is at a very high risk of having dementia right before symptoms even start,\u201d said Sinvani, who was not involved in the new research.<\/p>\n<p>\u201cThis\u00a0is\u00a0definitely a\u00a0big finding in terms of,\u00a0\u2018OK. Can\u00a0we\u00a0identify\u00a0people before they even have symptoms of dementia?&#8217;\u201d<\/p>\n<p>Blood tests are an up-and-coming method for identifying Alzheimer\u2019s. Yakobchuk Olena \u2013 stock.adobe.com<\/p>\n<p>Dementia symptoms can include memory loss, difficulties with familiar tasks, communication troubles, disorientation, poor judgment and mood or personality changes.<\/p>\n<p>An assessment of symptoms is used to diagnose Alzheimer\u2019s, along with a review of health history and physical and neurological exams. Brain imaging and a spinal fluid analysis can help confirm the diagnosis and rule out other conditions.<\/p>\n<p>Blood tests are an up-and-coming method for identifying Alzheimer\u2019s, with the <a href=\"https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-clears-first-blood-test-used-diagnosing-alzheimers-disease\" target=\"_blank\" rel=\"noopener\">US Food and Drug Administration recently approving<\/a> new blood testing for people 55 and older experiencing symptoms like memory loss.<\/p>\n<p>P-tau217 blood tests typically require a doctor\u2019s order, though <a href=\"https:\/\/truehealthlabs.com\/phosphorylated-tau-217-ptau217\/\" target=\"_blank\" rel=\"noopener\">one sells online for $229<\/a> with the promise that \u201cno doctor or insurance is needed.\u201d<\/p>\n<p>The new JAMA review, which included data from over 7,800 people, found that p-tau217 levels were much higher in amyloid-positive people than in amyloid-negative people, even though these individuals had no cognitive symptoms.<\/p>\n<p>Dementia symptoms can include memory loss, difficulties with familiar tasks, communication troubles, disorientation, poor judgment and mood or personality changes. LIGHTFIELD STUDIOS \u2013 stock.adobe.com<\/p>\n<p>Amyloid plaques are clumps of misfolded proteins in the brain that can disrupt brain function.<\/p>\n<p>It\u2019s a tell-tale sign of Alzheimer\u2019s.<\/p>\n<p>The problem is that there\u2019s no cure for amyloid plaques in the brain, though there are treatments that can reduce them in the early stages of Alzheimer\u2019s.<\/p>\n<p>\u201cThe question in my mind\u00a0is, at this moment, how many people would want to know\u00a0that they have\u00a0this\u00a0biomarker and have\u00a0a high\u00a0risk\u00a0of dementia?\u201d Sinvani mused.<\/p>\n<p>\u201cThe\u00a0reason why this isn\u2019t ready for primetime is because we\u00a0don\u2019t\u00a0have medications right now that would be offered,\u201d she continued, \u201cbut the goal is that if we can\u00a0identify\u00a0people\u00a0early enough, before they even start having symptoms, then we can potentially, hopefully as medications develop, be able to introduce medications that can prevent or slow down the progression.\u201d<\/p>\n<p>While there is no cure for Alzheimer\u2019s, <a href=\"https:\/\/nypost.com\/2025\/11\/28\/health\/alzheimers-risk-declines-sharply-with-one-daily-lifestyle-change-researchers-say\/\" target=\"_blank\" rel=\"noopener\">lifestyle changes<\/a> can lower the risk or potentially slow progression.<\/p>\n<p>\u201cA healthy diet, exercise, increased socialization, making connections and keeping your brain active,\u201d Sinvani said, \u201cthese are all things that can\u00a0impact\u00a0the trajectory of dementia, and so, knowing that you are at\u00a0very high\u00a0risk\u00a0could be\u00a0a nice\u00a0way\u00a0to\u00a0sort of incentivize\u00a0people to start doing something about it.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"There\u2019s new progress in the battle against Alzheimer\u2019s disease. About 1 in 9 US seniors has Alzheimer\u2019s, the&hellip;\n","protected":false},"author":3,"featured_media":425293,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[10263,6923,25482,632,151,210,12236,16978,67,132,68],"class_list":{"0":"post-425292","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-health","8":"tag-alzheimers-disease","9":"tag-blood","10":"tag-blood-tests","11":"tag-dementia","12":"tag-fda","13":"tag-health","14":"tag-northwell-health","15":"tag-study-says","16":"tag-united-states","17":"tag-unitedstates","18":"tag-us"},"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@us\/115664211785546236","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/posts\/425292","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/comments?post=425292"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/posts\/425292\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/media\/425293"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/media?parent=425292"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/categories?post=425292"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/tags?post=425292"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}