As anyone who has ever dieted will attest, losing weight is only half the problem. It\u2019s another matter entirely keeping it off for good.<\/p>\n
Now research is suggesting that the same is true for weight-loss medications. While these GLP-1 drugs make the dieting process easier by reducing appetite and cravings, decide to stop and the rebound effect can be stronger than ever, says Dr Jack Mosley<\/a>.<\/p>\n ‘Although the weight loss is real with the weight-loss medications, so is the rebound,’ Dr Jack said on Instagram. ‘Latest research shows that 20 months after stopping the GLP-1 weight-loss medications you will typically regain all of that weight you originally lost – and your cardio-metabolic markers such as your cholesterol, your glucose and your blood pressure will return to baseline as well.’<\/p>\n Worryingly, research suggests that weight regain is even faster after GLP-1s than a traditional diet. ‘This 2026 study highlighted that the weight regain is much faster than the weight regain you typically see after dieting without the weight-loss medications,’ says Dr Jack. In fact, ‘it was between four and up to eight times faster.’ <\/p>\n How to prevent \u2018rebound\u2019 weight gain<\/p>\n