{"id":668005,"date":"2026-03-20T00:57:16","date_gmt":"2026-03-20T00:57:16","guid":{"rendered":"https:\/\/www.europesays.com\/us\/668005\/"},"modified":"2026-03-20T00:57:16","modified_gmt":"2026-03-20T00:57:16","slug":"study-reveals-a-turning-point-when-your-bodys-aging-accelerates-sciencealert","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/us\/668005\/","title":{"rendered":"Study Reveals a Turning Point When Your Body’s Aging Accelerates : ScienceAlert"},"content":{"rendered":"

The passage of time may be linear, but the course of human aging<\/a> is not.<\/p>\n

Rather than a gradual transition, your life staggers and lurches through the rapid growth of childhood and the plateau of early adulthood<\/a>, to an acceleration in aging as the decades progress.<\/p>\n

A study identified a turning point at which that acceleration typically occurs: around age 50.<\/p>\n

After this time, the trajectory at which your tissues and organs age is steeper than the decades preceding, according to a study of proteins in human bodies across a wide range of adult ages<\/a> \u2013 and your veins are among the fastest to decline.<\/p>\n

“Based on aging-associated protein changes, we developed tissue-specific proteomic age clocks and characterized organ-level aging trajectories,” writes a team<\/a> led by scientists from the Chinese Academy of Sciences in their paper published in 2025.<\/p>\n

“Temporal analysis revealed an aging inflection around age 50, with blood vessels being a tissue that ages early and is markedly susceptible to aging.”<\/p>\n

Watch the video below for a summary:<\/p>\n

\"YouTube frameborder=”0\u2033 allow=”accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share” referrerpolicy=”strict-origin-when-cross-origin” allowfullscreen><\/p>\n

Humans have a remarkably long lifespan<\/a> compared to most other mammals<\/a>, but it comes with some costs. One is a decline in organ function<\/a>, leading to an increased risk of chronic disease<\/a> as the years mount<\/a>.<\/p>\n

We don’t have a very good understanding of the patterns of aging<\/a> in individual organs, so the team investigated how proteins in different tissues change over time<\/a>.<\/p>\n

“Our findings lay the groundwork for a systems-level understanding of human aging through the lens of proteins,” the researchers write<\/a>.<\/p>\n

\"AA graphic illustrating the role of proteins in human aging. (Ding et al., Cell, 2025)<\/p>\n

They collected tissue samples from a total of 76 organ donors between the ages of 14 and 68 who had died of accidental traumatic brain injury. They also obtained blood samples.<\/p>\n

The 516 samples \u2013 from 13 different tissues \u2013 covered seven of the body’s systems<\/a>: cardiovascular (heart and aorta), digestive (liver, pancreas, and intestine), immune (spleen and lymph node), endocrine (adrenal gland and white adipose), respiratory (lung), integumentary (skin), and musculoskeletal (muscle).<\/p>\n

The team constructed a catalogue of the proteins found in these systems, taking careful note of how their levels changed as the ages of the donors increased.<\/p>\n

“We identified tissue-enriched and tissue-enhanced proteins,” they write<\/a>, “as well as those common across tissues, which are vital for basic housekeeping functions in biology.”<\/p>\n

\"Subscribe<\/a><\/p>\n

The researchers compared their findings to a database of diseases and their associated genes, and found that expressions of 48 disease-related proteins increased with age.<\/p>\n

These included cardiovascular conditions<\/a>, tissue fibrosis, fatty liver disease, and liver-related tumors.<\/p>\n

The most stark changes occurred between the ages of 45 and 55, the researchers found.<\/p>\n

It’s at this point that many tissues undergo substantial proteomic remodeling, with the most marked changes occurring in the aorta<\/a> \u2013 demonstrating a strong susceptibility to aging<\/a>.<\/p>\n

The spleen<\/a> also showed sustained change, as did the pancreas<\/a> \u2013 an abdominal organ responsible for producing enzymes and hormones our bodies use to break down and absorb nutrients in our food<\/a>.<\/p>\n

\"StudyYour body’s organs according to when they’re most sensitive to aging. (Ding et al., Cell, 2025)<\/p>\n

To test their findings, the researchers isolated a protein associated with aging in the aortas of mice, and injected it into young mice to observe the results.<\/p>\n

Animals treated with the protein had reduced physical performance, decreased grip strength, lower endurance, and lower balance and coordination compared to non-treated mice. They also had prominent markers of vascular aging<\/a>.<\/p>\n

Muscle strength<\/a>, especially hand grip strength<\/a>, impacts our ability to manage age-related diseases<\/a> and injuries<\/a>, and 2024 research from Finland suggests<\/a> genetic factors that affect muscle strength might play a role in healthy aging.<\/p>\n

Previous work<\/a> by a US team showed another two peaks in aging, at around 44, and again at around 60.<\/p>\n

In that study, the first peak showed changes in molecules related to the metabolism of lipids, caffeine<\/a>, and alcohol<\/a>, as well as cardiovascular disease, and dysfunctions in skin and muscle.<\/p>\n

The second peak was associated with carbohydrate and caffeine<\/a> metabolism, cardiovascular disease, skin and muscle, immune regulation<\/a>, and kidney function<\/a>.<\/p>\n

Related: Popular Anti-Aging Supplement May Fuel Cancer Growth \u2013 Here’s Why<\/a><\/strong><\/p>\n

The findings in this 2025 paper suggest that human aging is a complicated, step-wise process involving different systems.<\/p>\n

Working out how aging is going to affect specific parts of the body at specific times<\/a> could help develop medical interventions to make the process easier.<\/p>\n

“Our study is poised to construct a comprehensive multi-tissue proteomic atlas spanning 50 years of the entire human aging process, elucidating the mechanisms behind proteostasis imbalance in aged organs and revealing both universal and tissue-specific aging patterns,” the authors write<\/a>.<\/p>\n

“These insights may facilitate the development of targeted interventions for aging and age-related diseases, paving the way to improve the health of older adults<\/a>.”<\/p>\n

The research was published in Cell<\/a>.<\/p>\n

An earlier version of this article was published in July 2025.<\/p>\n","protected":false},"excerpt":{"rendered":"The passage of time may be linear, but the course of human aging is not. Rather than a…\n","protected":false},"author":3,"featured_media":668006,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[210,352,67,132,68],"class_list":{"0":"post-668005","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-health","8":"tag-health","9":"tag-msft-content","10":"tag-united-states","11":"tag-unitedstates","12":"tag-us"},"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@us\/116258789733331505","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/posts\/668005","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/comments?post=668005"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/posts\/668005\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/media\/668006"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/media?parent=668005"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/categories?post=668005"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/us\/wp-json\/wp\/v2\/tags?post=668005"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}