GLP-1 medications have been on the rise for years due to their multifaceted weight-loss benefits. Now, getting your hands on a prescription doesn’t have to be a stressful situation. Instead, you can consult with a handful of online telehealth platforms and even your primary care doctor (or both!). Once you get your medication, don’t forget to add supplements to your daily routine to support your fitness goals and nutritional needs.

Dr. Wiljon Beltre, a board-certified, fellowship-trained bariatric and metabolic surgeon and the founder of Beltre Bariatrics in Orlando, Florida, says to think of GLP-1s as a biological reset button. “They mimic a natural hormone that your gut releases after a meal,” he says. “Their main job is to slow down how fast your stomach empties and tell your brain, ‘we’re full, you can stop thinking about food now.’”

That’s where supplements come in. When your appetite reduces or even disappears, you’re not just eating less food; you’re also getting fewer vitamins and minerals. “Supplements are essential to ensure your hair doesn’t thin, your bones stay strong, and your energy doesn’t drop with the weight,” explains Dr. Beltre.

Best Supplements to Take While on GLP-1s at a Glance

Best Overall: Happy Mammoth Prebiotic Collagen Protein, $70
Best Runner Up: Pure Encapsulations Magnesium (Glycinate), $27
Best Omega-3 Fish Oil: Nordic Naturals Omega-3, $20
Best Hybrid Supplement: Pure Encapsulations Vitamin D3 & K2, $19
Best Vitamin B12: Thorne Vitamin B12, $24
Best Digestive Enzymes: Happy V Debloat + Digest, $40 (30-day supply)
Best Vitamin D: Pure Encapsulations Vitamin D3 Liquid, $33
Best Fiber: Sakara Fiber Super Powder, $45
Best Electrolytes: Waterboy Daily Hydration, $40 (was $50)
Best Protein Powder: Promix Whey Protein Powder, $64
Best Multivitamin: Olly Women’s Multi, $16

Do You Need Supplements While on a GLP-1?

This simple answer is, yes, you need supplements while on a GLP-1 medication. Supplements are a supportive addition to your weight loss journey because these drugs often reduce appetite and total food intake, which may increase the risk of nutrient gaps. “Rapid weight loss can also affect body composition and hormone levels, including estrogen, which plays an important role in maintaining vaginal health and supporting protective lactobacillus bacteria,” says registered dietician Lenia Lopez. “Supporting nutrition and microbiome balance with targeted supplements may help the body adapt to metabolic and hormonal changes during weight loss.”

Lama Dalloul, clinical dietitian at Bioniq, also shares that thoughtful supplementation can help maintain overall nutritional balance, support muscle health when protein intake is low, aid energy metabolism and cognitive function, and promote gut health and digestion, especially if gastrointestinal side effects occur. Here are the top supplements you should consider:

  • Collagen
  • Vitamin B-12
  • Protein
  • Vitamin D
  • Fiber
  • Electrolytes
  • Multi-Vitamins

“I started a micro-dose GLP-1 regimen four months ago, about one year postpartum,” Gina Vaynshteyn, VP, Commerce, says. “Even though the dosage was low, I still dealt with fatigue from not getting enough nutrients, which made going to the gym even more of a struggle. Plus, GLP-1s tend to constipate you, so…there was also that. Supplementing my dosage and diet with protein, vitamin B-12, fiber, and electrolytes truly made a world of difference.”

Ahead, shop the best supplements to take while on a GLP-1 medication from Happy Mammoth, Olly, Thorne, and more.

Happy Mammoth and iHerb are Flow Space sponsors, however, all products in this article were independently selected by our editors. Please note that if you purchase something by clicking on a link within this story, we may receive a small commission of the sale.

The Best Supplements to Take While on GLP-1s

  • Happy Mammoth Prebiotic Collagen Protein

    Happy Mammoth Prebiotic Collagen Protein
    Image Credit: Happy Mammoth

    Best overall

    Happy Mammoth Prebiotic Collagen Protein

    Experts recommend supplementing with prebiotics, collagen, and protein, which is why Happy Mammoth’s Prebiotic Collagen Protein mixture is a perfect addition to your GLP-1 journey. It helps to maintain muscle mass, which many users report they struggle with while on the medication. The easily dissolvable powder also helps balance the gut microbiome, which “can assist in reducing cravings and improving satiety,” per the brand. This supplement is free from fillers, soy, gluten, and artificial additives.

    Form: Powder
    Serving Size: 1 scoop
    Flavors: Vanilla
    Who is it best for? Anyone looking to maintain muscle mass and relieve constipation. It really is a great all-in-one option.

  • Pure Encapsulations Magnesium (Glycinate)

    Pure Encapsulations Magnesium (Glycinate)
    Image Credit: iHerb

    Best Runner Up

    Pure Encapsulations Magnesium (Glycinate)

    Magnesium plays an essential role in hundreds of processes throughout the body, including muscle and nerve function, energy production, and bone health. It’s also commonly used to support relaxation and restful sleep, making it an excellent option for those looking to maintain their overall wellness while on a GLP-1. The Pure Encapsulations Magnesium (Glycinate) is a popular choice because it contains one of the most well-absorbed forms of magnesium, making it ideal for daily supplementation.

    Form: Capsule
    Serving Size: 1 capsule
    Flavors: None
    Who is it best for? Anyone who experiences gastrointestinal upset from other magnesium forms.

  • Nordic Naturals Omega-3

    Nordic Naturals Omega-3
    Image Credit: Nordic Naturals

    Omega-3 Fish Oil

    Nordic Naturals Omega-3

    Don’t forget to prioritize nutrient-dense foods, especially healthy fats like Omega-3 fatty acids, particularly EPA and DHA, which support heart, brain, and eye health, according to experts. If you’re not regularly consuming fatty fish like salmon or sardines, an omega-3 supplement helps fill that nutritional gap. Nordic Naturals Omega-3 comes with glowing reviews thanks to its high-quality triglyceride-form fish oil, designed for optimal absorption and purity. Plus, there isn’t a pungent fishy aftertaste.

    Form: Capsule
    Serving Size: 2 soft gels
    Flavors: None
    Who is it best for? Those looking for a fish oil without the typical fishy aftertaste.

  • Pure Encapsulations Vitamin D3 & K2

    Pure Encapsulations Vitamin D3 & K2
    Image Credit: Pure Encapsulations

    Best Hybrid Supplement

    Pure Encapsulations Vitamin D3 & K2

    Vitamin D is an essential nutrient that supports bone, muscle, and immune health, while vitamin K2 works alongside it to help direct calcium to the bones. For people taking a GLP-1 medication, maintaining adequate vitamin D intake goes hand in hand with supporting nutrition as eating habits change. This hybrid vitamin from Pure Encapsulations combines the two nutrients in a single easy-to-take formula and comes in 60 capsules, making it a convenient option to incorporate into your daily routine.

    Form: Capsule
    Serving Size: 1 capsule
    Flavors: None
    Who is it best for? Those needing a high-dose supplement.

  • Thorne Vitamin B12

    Thorne Vitamin B12
    Image Credit: Thorne

    Best Vitamin B12

    Thorne Vitamin B12

    Dr. Beltre says many GLP-1 users experience fatigue, and B12 supports energy metabolism and nerve function, which can be affected by the meds and reduced food intake. Thorne’s daily B-12 vitamin are a breeze to take, with no pesky aftertaste or side effects. Each capsule contains an active, tissue-ready form of vitamin B12, which supports energy production, heart and eye health, red blood cell formation, and more.

    Form: Pill
    Serving Size: 1 capsule daily
    Flavors: None
    Who is it best for? Those with fatigue

  • Happy V Debloat + Digest

    Happy V Debloat + Digest
    Image Credit: Happy V

    Best Digestive Enzymes

    Happy V Debloat + Digest

    “Digestive enzymes help break down proteins, fats, and carbohydrates into smaller molecules that can be absorbed in the intestine,” Lopez explains. “Because GLP-1 therapies can reduce appetite and overall food intake, maximizing nutrient utilization from smaller meals may be beneficial.” Digestive enzymes may also help support digestion and digestive comfort (such as bloating or fullness).

    Happy V’s enzymes promise relief within 30 minutes, support regular bowel movements, and target abdominal pain and gas. The capsules are crafted with science-backed ingredients, including peppermint powder, ginger extract, and sodium. Don’t let the sodium deter you; it helps ease upset stomachs and acid indigestion.

    Form: Pill
    Serving Size: 2 capsules daily
    Flavors: None
    Who is it best for? People experiencing bloating and constipation

  • Pure Encapsulations Vitamin D3 Liquid

    Pure Encapsulations Vitamin D3 Liquid
    Image Credit: Pure Encapsulations

    Best Vitamin D

    Pure Encapsulations Vitamin D3 Liquid

    Dalloul explains that vitamin D combined with calcium is important for bone health, immune function, and overall metabolism, “particularly if intake decreases or weight loss is rapid.” This pick from Pure Encapsulations comes in a liquid form, making it easy to tak espcially for those who don’t prefer pills. The liquid is supported by science to reach the bloodstream more quickly than other forms of vitamin D.

    Form: Liquid
    Serving Size: 1–7 drops daily with food
    Flavors: None
    Who is it best for? Those losing muscle mass

  • Sakara Fiber Super Powder

    Sakara Fiber Super Powder
    Image Credit: Sakara

    Best FIber

    Sakara Fiber Super Powder

    “Because meds slow the gut down, things can get ‘stuck’, so I always recommend a daily fiber supplement to keep everything moving as it should,” Beltre says. Sakara’s Fiber Super Powder combines 10 unique prebiotic fruits and vegetables with 10 diverse digestive enzymes to support a thriving microbiome and digestion.

    Form: Powder
    Serving Size: 1 scoop
    Flavors: Hint of pineapple
    Who is it best for? Anyone who needs to boost daily fiber intake

  • Waterboy Daily Hydration

    Waterboy Daily Hydration
    Image Credit: Waterboy

    Best Electrolytes

    Waterboy Daily Hydration

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    Dr. Beltre recommends adding an electrolyte to your diet that contains magnesium and potassium. “Rapid weight loss can lead to water loss, and if you feel dizzy or get leg cramps, you’re probably low on electrolytes,” he says. “Magnesium can also help with sleep and muscle recovery.

    Snag the Waterboy Daily Hydration packs that are easy to toss in your bag, so never have to worry about dizzy spells and feeling faint. Each pack contains a blend of Himalayan sea salt, potassium citrate, ascorbic acid (vitamin C), magnesium citrate, L-theanine, ginger extract, organic stevia extract, and vitamin B12. The best part? It tastes like a watermelon candy without all the sugar and chemicals.

    Form: Powder
    Serving Size: 1 pack
    Flavors: Watermelon, strawberry lemonade, cucumber citrus, and blue raspberry
    Who is it best for? People strugglnig with hydration and dizziness

  • Promix Whey Protein Powder

    Promix Whey Protein Powder
    Image Credit: Promix

    Best Protein Powder

    Promix Whey Protein Powder

    One of the most important supporting supplements you can add to your routine is protein. When you’re placed on a GLP-1 medication, your provider should discuss your protein goals. “Because you can’t eat big meals, you need to supplement with protein to preserve muscle,” Dr. Beltre explains. “If you lose too much, your metabolism can crash, which will make it next to impossible to keep the weight off later.”

    The Promix Whey Protein Powder is simple to add to water, smoothies, coffee, and your other favorite drinks. It’s crafted with grass-fed whey, rich in antioxidants and healthy fats that support muscle mass. It’s free of hormones and added sugars, so you can stay on track with your nutritional goals.

    Form: Powder
    Serving Size: Two scoops
    Flavors: Unflavored, peanut butter, raw chocolate, vanilla, and 4 more
    Who is it best for? Those with sensitive digestive needs and people looking to meet protein goals

  • Olly Women’s Multi

    Olly Women's Multi
    Image Credit: Olly

    Best Multivitamin

    Olly Women’s Multi

    The Olly Women’s Multi helps bridge the gap that comes with rapid weight loss. The formula contains vitamins A, C, D, E, Bs, biotin, and folic acid that help to support immune system health, bone health, and more.

    Form: Gummy
    Serving Size: 2 gummies a day
    Flavors: Blissful berry
    Who is it best for? Women of all ages