• Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA

    Seung Hoan Choi, Sean J. Jurgens, Ling Xiao, Matthew C. Hill, Valerie N. Morrill, Lu-Chen Weng, James P. Pirruccello, Helene Mantineo, Carolina Roselli, Jennifer L. Halford, Mark D. Chaffin, Victor Nauffal, Xin Wang, Steven A. Lubitz & Patrick T. Ellinor

  • Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA

    Seung Hoan Choi & Kathryn L. Lunetta

  • Department of Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences (Heart Failure & Arrhythmias), Amsterdam UMC, Amsterdam, The Netherlands

    Sean J. Jurgens & Connie R. Bezzina

  • Cardiovascular Research Center, Massachsetts General Hospital, Harvard Medical School, Boston, MA, USA

    Ling Xiao, Matthew C. Hill, Lu-Chen Weng, James P. Pirruccello, Jennifer L. Halford, Victor Nauffal, Xin Wang, Steven A. Lubitz & Patrick T. Ellinor

  • Department of Translational Data Science and Informatics, Geisinger, Danville, PA, USA

    Christopher M. Haggerty

  • deCODE genetics/Amgen, Reykjavik, Iceland

    Garðar Sveinbjörnsson, David O. Arnar, Daniel Fannar Gudbjartsson, Hilma Holm & Kari Stefansson

  • TIMI Study Group, Boston, MA, USA

    Nicholas A. Marston, Christian T. Ruff & Marc S. Sabatine

  • Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Nicholas A. Marston, Christian T. Ruff & Marc S. Sabatine

  • Division of Cardiology, University of California, San Francisco, San Francisco, CA, USA

    James P. Pirruccello & Gregory M. Marcus

  • Cardiovascular Center, Landspitali – The National University Hospital of Iceland, Reykjavik, Iceland

    David O. Arnar

  • Faculty of Medicine, University of Iceland, Reykjavik, Iceland

    David O. Arnar & Kari Stefansson

  • Faculty of Electical and Computer Engineering and School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland

    Daniel Fannar Gudbjartsson

  • Department of Medicine I, University Hospital Munich, Ludwig Maximilian University, Munich, Germany

    Aenne S. von Falkenhausen, Moritz F. Sinner & Stefan Kaab

  • German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany

    Aenne S. von Falkenhausen, Moritz F. Sinner & Stefan Kaab

  • Texas Cardiac Arrhythmia Institute, St David’s Medical Center, Austin, TX, USA

    Andrea Natale & Sanghamitra Mohanty

  • Department of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway

    Arnljot Tveit & Ingrid E. Christophersen

  • Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

    Bastiaan Geelhoed, Pim van der Harst & Michiel Rienstra

  • Department of Cardiovascular & Metabolic Sciences, Cleveland Clinic, Cleveland, OH, USA

    David R. Van Wagoner & Jonathan D. Smith

  • Division of Cardiology, University of Illinois at Chicago, Chicago, IL, USA

    Dawood Darbar

  • Atrial Fibrillation NETwork (AFNET), Münster, Germany

    Doreen Haase, Renate B. Schnabel & Paulus Kirchhof

  • Epidemiological Cardiology Research Center (EPICARE), Department of Internal Medicine, Cardiology Section, Wake Forest School of Medicine, Winston-Salem, NC, USA

    Elsayed Z. Soliman

  • Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USA

    Giovanni E. Davogustto, Quinn S. Wells, Zachary T. Yoneda, M. Benjamin Shoemaker & M. Benjamin Shoemaker

  • Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA

    Goo Jun

  • Cardiac Arrhythmia Service, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Hugh Calkins

  • Intermountain Heart Institute, Intermountain Medical Center, Murray, UT, USA

    Jeffrey L. Anderson, Stacey Knight & Michael J. Cutler

  • Division of Cardiology, University of Utah, Salt Lake City, UT, USA

    Jeffrey L. Anderson

  • Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA

    Jennifer A. Brody, Joshua C. Bis, Bruce M. Psaty & Nona Sotoodehnia

  • Departments of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA

    John Barnard

  • Department of Epidemiology, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA

    John E. Hokanson & Kendra Young

  • Department of Clinical Physiology, Department of Clinical Sciences, Skåne University Hospital and Lund University, Lund, Sweden

    Linda S. B. Johnson

  • Institute of Laboratory Medicine, Faculty of Medical Sciences, Private University of the Principality of Liechtenstein, Triesen, Liechtenstein

    Lorenz Risch

  • Center of Laboratory Medicine, University Institute of Clinical Chemistry, University of Bern, Inselspital, Bern, Switzerland

    Lorenz Risch

  • Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, Western University, London, Ontario, Canada

    Lorne J. Gula & Jason D. Roberts

  • Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA

    Lydia Coulter Kwee

  • Cardiology/Electrophysiology, University Hospital Basel, University of Basel, Basel, Switzerland

    Michael Kühne

  • The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Michael Preuss, Roelof A. J. Smit & Ruth J. F. Loos

  • Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA

    Namrata Gupta, Stacey Gabriel & Daniel I. Chasman

  • Division of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA

    Navid A. Nafissi & Svati H. Shah

  • Department of Epidemiology, University of Washington, Seattle, WA, USA

    Nicholas L. Smith & Bruce M. Psaty

  • Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA

    Nicholas L. Smith & Susan R. Heckbert

  • Department of Clinical Sciences, Clinical Research Center, Lund University, Malmö, Sweden

    Peter M. Nilsson

  • Department of Internal Medicine, Skåne University Hospital, Malmö, Sweden

    Peter M. Nilsson

  • Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands

    Pim van der Harst

  • Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA

    Quinn S. Wells & Dan M. Roden

  • Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Renae L. Judy & Scott M. Damrauer

  • Department of Surgery, Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, USA

    Renae L. Judy & Scott M. Damrauer

  • Department of Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany

    Renate B. Schnabel & Paulus Kirchhof

  • German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg/Kiel/Lübeck, Germany

    Renate B. Schnabel & Paulus Kirchhof

  • Molecular Cardiology Division, Victor Chang Cardiac Research Institute, Sydney, New South Wales, Australia

    Renee Johnson & Diane Fatkin

  • School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia

    Renee Johnson & Diane Fatkin

  • Department of Medicine, University of Utah, Salt Lake City, UT, USA

    Stacey Knight

  • Department of Bio-Informational Pharmacology, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan

    Tetsushi Furukawa

  • Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA

    Thomas W. Blackwell

  • Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA

    Yuan-I Min

  • Department of Medicine and the School of Biomedical Engineering, University of British Columbia, Vancouver, British Columbia, Canada

    Zachary W. M. Laksman

  • Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA

    Alvaro Alonso

  • Department of Cardiology, Smidt Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA

    Christine M. Albert

  • McKusick–Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Dan E. Arking

  • Divisions of Preventive Medicine and Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Daniel I. Chasman

  • Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA

    Daniel J. Rader & Scott M. Damrauer

  • Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada

    David Conen

  • University of Massachusetts Chan Medical School Worcester, Worcester, MA, USA

    David D. McManus

  • Cardiology Department, St. Vincent’s Hospital, Sydney, New South Wales, Australia

    Diane Fatkin

  • NHLBI and Boston University’s Framingham Heart Study, Framingham, MA, USA

    Emelia J. Benjamin & Kathryn L. Lunetta

  • Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston Medical Center, Boston, MA, USA

    Emelia J. Benjamin

  • Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA

    Eric Boerwinkle

  • Department of Medical Genetics, Oslo University Hospital, Oslo, Norway

    Ingrid E. Christophersen

  • Department of Cardiology, Lund University Diabetes Center and Wallenberg Center for Molecular Medicine, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden

    J. Gustav Smith

  • The Wallenberg Laboratory/Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University and the Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden

    J. Gustav Smith

  • Population Health Research Institute, McMaster University, and Hamilton Health Sciences, Hamilton, Ontario, Canada

    Jason D. Roberts

  • Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    Laura M. Raffield

  • Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA

    Michael H. Cho

  • Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, USA

    Mina K. Chung

  • Laboratory for Molecular Cardiology, Department of Cardiology, Centre for Cardiac, Vascular, Pulmonary and Infectious Diseases, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark

    Morten S. Olesen

  • Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Copenhagen, Copenhagen, Denmark

    Morten S. Olesen

  • Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK

    Paulus Kirchhof

  • Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

    Ruth J. F. Loos

  • Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA

    Saman Nazarian

  • Dell Medical School, Austin, TX, USA

    Sanghamitra Mohanty

  • Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington, Seattle, WA, USA

    Susan R. Heckbert

  • Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women’s Hospital, Boston, MA, USA

    Susan Redline

  • Department of Human Genetics and Disease Diversity, Tokyo Medical and Dental University (TMDU) Graduate School of Medical and Dental Sciences, Tokyo, Japan

    Toshihiro Tanaka

  • BioResource Research Center, Tokyo Medical and Dental University (TMDU), Tokyo, Japan

    Toshihiro Tanaka

  • Life Science and Bioethics Research Center, Tokyo Medical and Dental University (TMDU), Tokyo, Japan

    Yusuke Ebana

  • Demoulas Center for Cardiac Arrhythmias, Massachusetts General Hospital, Boston, MA, USA

    Steven A. Lubitz & Patrick T. Ellinor

  • Regeneron Genetics Center, Tarrytown, NY, USA

    Goncalo Abecasis, Xiaodong Bai, Suganthi Balasubramanian, Aris Baras, Christina Beechert, Boris Boutkov, Michael Cantor, Giovanni Coppola, Tanima De, Andrew Deubler, Aris Economides, Gisu Eom, Manuel A. R. Ferreira, Caitlin Forsythe, Erin D. Fuller, Zhenhua Gu, Lukas Habegger, Alicia Hawes, Marcus B. Jones, Katia Karalis, Shareef Khalid, Olga Krasheninina, Rouel Lanche, Michael Lattari, Dadong Li, Alexander Lopez, Luca A. Lotta, Kia Manoochehri, Adam J. Mansfield, Evan K. Maxwell, Jason Mighty, Lyndon J. Mitnaul, Mona Nafde, Jonas Nielsen, Sean O’Keeffe, Max Orelus, John D. Overton, Maria Sotiropoulos Padilla, Razvan Panea, Tommy Polanco, Manasi Pradhan, Ayesha Rasool, Jeffrey G. Reid, William Salerno, Thomas D. Schleicher, Alan Shuldiner, Katherine Siminovitch, Jeffrey C. Staples, Ricardo H. Ulloa, Niek Verweij, Louis Widom, Sarah E. Wolf & Gonçalo Abecasis

  • University of Michigan, Ann Arbor, MI, USA

    Goncalo Abecasis, Gonçalo Abecasis, Larry Bielak, Jeffrey Curtis, Matthew Flickinger, Colin Gross, Hyun Min Kang, Sharon Kardia, Jonathon LeFaive, Patricia Peyser, Jacob Pleiness, Albert Vernon Smith, Jennifer Smith, Daniel Taliun, Peter VandeHaar, Jiongming Wang, Joshua Weinstock, Cristen Willer, Ketian Yu, Wei Zhao & Sebastian Zoellner

  • New York Genome Center, New York, NY, USA

    Namiko Abe, Karen Bunting, Bo-Juen Chen, Heather Geiger, Soren Germer, Melissa Marton, Catherine Reeves, Nicolas Robine, Alexi Runnels, Tanja Smith, Lara Winterkorn & Michael Zody

  • Broad Institute of MIT and Harvard, Cambridge, MA, USA

    Francois Aguet, Kristin Ardlie, Clary Clish, Pradeep Natarajan & Seyedeh Maryam Zekavat

  • Children’s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA

    Laura Almasy

  • University of Maryland, College Park, MD, USA

    Seth Ament, Amber Beitelshees, Christy Chang, Coleen Damcott, Scott Devine, Mao Fu, Da-Wei Gong, Yue Guan, Daniel Harris, Elliott Hong, Michael Kessler, Joshua Lewis, Patrick McArdle, Braxton D. Mitchell, May E. Montasser, James Perry, Toni Pollin, Robert Reed, Kathleen Ryan, Shabnam Salimi, Amol Shetty, Elizabeth Streeten, Simeon Taylor & Huichun Xu

  • University of Washington, Seattle, WA, USA

    Peter Anderson, Jai Broome, Erin Buth, Matthew Conomos, Colleen Davis, Leslie Emery, Chris Frazar, Stephanie M. Fullerton, Stephanie Gogarten,  Ben Heavner, Craig Johnson, Alyna Khan, Cathy Laurie, Cecelia Laurie, David Levine, Susanne May, Daniel McGoldrick, Caitlin McHugh, Sarah C. Nelson, Deborah Nickerson, Ken Rice, Josh Smith, Adrienne M. Stilp, Adam Szpiro, Timothy A. Thornton, Machiko Threlkeld, David Tirschwell, Catherine Tong, Fei Fei Wang, Bruce Weir, Kayleen Williams & Quenna Wong

  • University of Mississippi, Oxford, MS, USA

    Pramod Anugu, Adolfo Correa, Lynette Ekunwe, Yan Gao, Michael Hall, Hao Mei & Nancy Min

  • National Institutes of Health, Bethesda, MD, USA

    Deborah Applebaum-Bowden

  • University of Kentucky, Lexington, KY, USA

    Donna K. Arnett

  • Duke University, Durham, NC, USA

    Allison Ashley-Koch, Yongmei Liu & Marilyn Telen

  • University of Alabama, Tuscaloosa, AL, USA

    Stella Aslibekyan, Bertha Hidalgo, Marguerite Ryan Irvin, Merry-Lynn McDonald & Hemant Tiwari

  • Stanford University, Palo Alto, CA, USA

    Tim Assimes, Carlos Bustamante, Chris Gignoux, Yu Liu, Emmanuel Mignot, David T. Paik, Marco Perez, Michael Snyder, Hua Tang & Joseph Wu

  • Medical College of Wisconsin, Milwaukee, WI, USA

    Paul Auer & Ulrich Broeckel

  • Johns Hopkins University, Baltimore, MD, USA

    Dimitrios Avramopoulos, Emily Barron-Casella, Terri Beaty, Diane Becker, Lewis Becker, James Casella, Kimberly Jones, Barry Make, Rasika Mathias, Rakhi Naik, Wendy Post, Ingo Ruczinski, Steven Salzberg, Margaret Taub, Dhananjay Vaidya & Lisa Yanek

  • Providence Health Care, Vancouver, British Columbia, Canada

    Najib Ayas, Jeff O’Connell & Tim O’Connor

  • Baylor College of Medicine Human Genome Sequencing Center, Houston, TX, USA

    Adithya Balasubramanian, Huyen Dinh, Harsha Doddapaneni, Shannon Dugan-Perez, Jesse Farek, Richard Gibbs, Yi Han, Jianhong Hu, Deepti Jain, Ziad Khan, Sandra Lee, Vipin Menon, Ginger Metcalf, Zeineen Momin, Donna Muzny, Caitlin Nessner, Osuji Nkechinyere, Geoffrey Okwuonu, Mahitha Rajendran, Sejal Salvi, Jireh Santibanez & Jennifer Watt

  • Tempus, University of Colorado Anschutz Medical Campus, Aurora, CO, USA

    Kathleen Barnes

  • Columbia University, New York, NY, USA

    R. Graham Barr & Danish Saleheen

  • The Emmes Corporation, Rockville, MD, USA

    Lucas Barwick

  • Cleveland Clinic, Fairfax, OH, USA

    Gerald Beck, Suzy Comhair & Serpil Erzurum

  • National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA

    Rebecca Beer, Weiniu Gan, Cashell Jaquish, Andrew Johnson,  Dan Levy, James Luo, Julie Mikulla, George Papanicolaou & Pankaj Qasba

  • University of Pittsburgh, Pittsburgh, PA, USA

    Takis Benos, Mark Geraci, Mark Gladwin, Ryan L. Minster, Frank Sciurba, Daniel E. Weeks & Yingze Zhang

  • Fundação de Hematologia e Hemoterapia de Pernambuco – Hemope, Recife, Pernambuco, Brazil

    Marcos Bezerra

  • School of Medicine, University of Texas Rio Grande Valley, Edinburg, TX, USA

    John Blangero, Joanne Curran, Ravi Duggirala, Harald Goring, Michael Mahaney & Juan Manuel Peralta

  • Wake Forest Baptist Health, Winston-Salem, NC, USA

    Donald W. Bowden, David Herrington, Nicholette Palmer & Beverly Snively

  • National Jewish Health, Denver, CO, USA

    Russell Bowler, James Crapo, Tasha Fingerlin, Elizabeth Regan & Snow Xueyan Zhao

  • University of Texas Health at Houston, Houston, TX, USA

    Deborah Brown, Paul de Vries, Myriam Fornage & James Hixson

  • University of California San Francisco, San Francisco, CA, USA

    Esteban Burchard, Ryan Hernandez & Shannon Kelly

  • Brigham and Women’s Hospital, Boston, MA, USA

    Brian Cade, Vincent Carey, Juan P. Casas Romero, Peter Castaldi, Dawn DeMeo, Auyon Ghosh, Craig Hersh, Brian Hobbs, Meryl LeBoff, Jiwon Lee, JoAnn Manson, Matt Moll, Dandi Qiao, Edwin Silverman, Tamar Sofer, Jessica Lasky Su, Jody Sylvia, Scott T. Weiss & Carla Wilson

  • University of Colorado at Denver, Denver, CO, USA

    Jonathan Cardwell, Sameer Chavan, Michelle Daya, Shanshan Gao, Daniel Grine, Greg Kinney, Ethan Lange, Leslie Lange, Susan Mathai, Bonnie Neltner, Julia Powers Becker, Meher Preethi Boorgula, Nicholas Rafaels, Pamela Russell, David Schwartz, Aniket Shetty, Garrett Storm, Tarik Walker, Avram Walts & Ivana Yang

  • University of Montreal, Montreal, Quebec, Canada

    Julie Carrier

  • Washington State University, Pullman, WA, USA

    Cara Carty

  • University of California, Los Angeles, CA, USA

    Richard Casaburi, Carolyn Crandall & Karol Watson

  • National Taiwan University, Taipei, Taiwan

    Yi-Cheng Chang & Lee-Ming Chuang

  • University of Virginia, Charlottesville, VA, USA

    Wei-Min Chen, Charles Farber, Ani Manichaikul, Josyf C. Mychaleckyj, Aakrosh Ratan & Stephen Rich

  • Lundquist Institute, Torrance, CA, USA

    Yii-Der Ida Chen, Xiuqing Guo, Xiaohui Li, Henry Lin, Jerome Rotter, Kevin Sandow & Kent D. Taylor

  • National Health Research Institute Taiwan, Zhunan, Taiwan

    Ren-Hua Chung & Chao Agnes Hsiung

  • University of Vermont, Burlington, VT, USA

    Elaine Cornell, Jon Peter Durda & Russell Tracy

  • Boston University, Boston, MA, USA

    L. Adrienne Cupples, Honghuang Lin, Gina Peloso & Vasan S. Ramachandran

  • Vitalant Research Institute, San Francisco, CA, USA

    Brian Custer

  • University of Chicago, Chicago, IL, USA

    Sean David

  • Mayo Clinic, Rochester, MN, USA

    Mariza de Andrade

  • Washington University in St. Louis, St. Louis, MO, USA

    Lisa de las Fuentes, Susan K. Dutcher, Lucinda Fulton, C. Charles Gu, D. C. Rao, Karen Schwander & Yun Ju Sung

  • Vanderbilt University, Nashville, TN, USA

    Michael DeBaun

  • University of Cincinnati, Cincinnati, OH, USA

    Ranjan Deka

  • University of North Carolina, Chapel Hill, NC, USA

    Qing Duan, Nora Franceschini, Yun Li & Kari North

  • Brown University, Providence, RI, USA

    Charles Eaton, Simin Liu & Stephen McGarvey

  • Harvard University, Cambridge, MA, USA

    Adel El Boueiz, Wonji Kim, Sean McFarland & Vijay G. Sankaran

  • Fred Hutchinson Cancer Research Center, Seattle, WA, USA

    Margery Gass, Jeff Haessler, Charles Kooperberg, Ulrike Peters & Lesley Tinker

  • Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Bruce Gelb, Eimear Kenny & Girish Nadkarni

  • Beth Israel Deaconess Medical Center, Boston, MA, USA

    Robert Gerszten & James Wilson

  • Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA

    David Glahn

  • University of Colorado Anschutz Medical Campus, Aurora, CO, USA

    Sharon Graw, Luisa Mestroni & Matthew Taylor

  • Mass General Brigham, Boston, MA, USA

    Kathryn J. Gray

  • McGill University, Montréal, Quebec, Canada

    David M. Haas & John Kimoff

  • University of Calgary, Calgary, Alberta, Canada

    Patrick Hanly

  • Yale University, New Haven, CT, USA

    Nicola L. Hawley

  • Tulane University, New Orleans, LA, USA

    Jiang He

  • University of Iowa, Iowa City, IA, USA

    Karin Hoth & Robert Wallace

  • Tri-Service General Hospital National Defense Medical Center, Taipei, Taiwan

    Yi-Jen Hung

  • Blood Works Northwest, Seattle, WA, USA

    Haley Huston, Jill Johnsen, Barbara Konkle & Sarah Ruuska

  • Taichung Veterans General Hospital Taiwan, Taichung, Taiwan

    Chii Min Hwu, Wen-Jane Lee & Wayne Hui-Heng Sheu

  • Oklahoma State University Medical Center, Tulsa, OK, USA

    Rebecca Jackson

  • Emory University, Atlanta, GA, USA

    Rich Johnston, Lawrence S. Phillips, Zhaohui Qin, Vivien Sheehan & Stephanie L. Sherman

  • Albert Einstein College of Medicine, New York, NY, USA

    Robert Kaplan & Sylvia Smoller

  • Loyola University, Chicago, IL, USA

    Holly Kramer

  • Harvard School of Public Health, Boston, MA, USA

    Christoph Lange & Xihong Lin

  • Ohio State University, Columbus, OH, USA

    Ulysses Magalang

  • Broad Institute of MIT and Harvard, Massachusetts General Hospital, Cambridge, MA, USA

    Alisa Manning

  • George Washington University, Washington, DC, USA

    Lisa Martin

  • RTI International, Research Triangle Park, NC, USA

    Becky McNeil & Cora Parker

  • Massachusetts General Hospital, Boston, MA, USA

    James Meigs

  • University of Arizona, Tucson, AZ, USA

    Deborah A. Meyers

  • National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA

    Mollie Minear

  • Oklahoma Medical Research Foundation, Oklahoma City, OK, USA

    Courtney Montgomery

  • Ministry of Health, Government of Samoa, Apia, Samoa

    Take Naseri

  • Howard University, Washington, DC, USA

    Sergei Nekhai

  • University at Buffalo, Buffalo, NY, USA

    Heather Ochs-Balcom

  • University of Pennsylvania, Philadelphia, PA, USA

    Allan Pack & Sarah Tishkoff

  • University of Minnesota, Minneapolis, MN, USA

    James Pankow, Michael Tsai & Scott Vrieze

  • Northwestern University, Evanston, IL, USA

    Laura Rasmussen-Torvik

  • Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA

    Alex Reiner

  • Lutia I Puava Ae Mapu I Fagalele, Apia, Samoa

    Muagututi’a Sefuiva Reupena

  • University of Ottawa, Ottawa, Ontario, Canada

    Rebecca Robillard

  • Universidade de Sao Paulo, Sao Paulo, Brazil

    Ester Cerdeira Sabino

  • Harvard Medical School, Boston, MA, USA

    Christine Seidman & Jonathan Seidman

  • Université Laval, Quebec City, Quebec, Canada

    Frédéric Sériès

  • UMass Memorial Medical Center, Worcester, MA, USA

    Brian Silver

  • University of Saskatchewan, Saskatoon, Saskatchewan, Canada

    Robert Skomro

  • University of Southern California, Los Angeles, CA, USA

    David Van Den Berg

  • Brigham and Women’s Hospital, Mass General Brigham, Boston, MA, USA

    Heming Wang

  • Indiana University, Bloomington, IN, USA

    Jennifer Wessel

  • Henry Ford Health System, Detroit, MI, USA

    L. Keoki Williams

  • Case Western Reserve University, Cleveland, OH, USA

    Xiaofeng Zhu

    • S.H.C, S.J.J., S.A.L. and P.T.E. conceived and designed the study. S.H.C., S.J.J., V.N.M., N.A.M., L.-C.W., J.P.P., G.J., C.R. and J.L.H. performed data curation and data processing for the discovery datasets. S.H.C. and S.J.J. performed the main statistical and bioinformatic analyses in the discovery datasets. A.S.v.F., A.N., A.T., B.G., D.R.V.W., D.D., D.H., E.Z.S., G.E.D., H.C., J.L.A., J.A.B., J.B., J.E.H., J.D.S., J.C.B., K.Y., L.S.B.J., L.R., L.J.G., L.C.K., M.K., M.P., N.A.N., N.L.S., P.M.N., P.v.d.H., Q.S.W., R.L.J., R.S., R.J., R.A.J.S., S. Knight, T.F., T.W.B., Y.-I.M., Z.T.Y., Z.W.M.L., C.R.B., A.A., B.M.P., C.M.A., D.E.A., D.M.R., D.I.C., D.J.R., D.C., D.D.M., D.F., E.J.B., E.B., G.M.M., I.E.C., J.G.S., J.D.R., L.M.R., M.B.S., M.H.C., M.J.C., M.R., M.K.C., M.S.O., M.F.S., N.S., P.K., R.J.F.L., S.N., S.M., S.M.D., S. Kaab, S.R.H., S.R., S.H.S., T.T., Y.E., C.T.R., M.S.S., K.L.L., S.A.L. and P.T.E. were involved in site-specific sample ascertainment, phenotype data collection, DNA collection for sequencing, data processing or supervision for the TOPMed-CCDG, CCDG and FOURIER datasets. N.G. and S.G. were involved in the coordination of sequencing at the Broad Institute for various discovery datasets. V.N.M., N.A.M., L.-C.W., J.P.P., C.R., M.D.C., V.N. and X.W. contributed critically to the analysis plan. C.M.H. performed data curation and bioinformatic analyses for the Geisinger MyCode dataset, with contributions from Regeneron Genetics Center authors, as specified in Supplementary Note. G.S., D.O.A. and D.F.G. were responsible for data curation and bioinformatic analyses in the deCODE dataset. H.H. and K.S. were responsible for coordination and supervision of the deCODE dataset. L.X., M.C.H. and H.M. were responsible for the functional studies of KDM5B, including CRISPR knockout, optical mapping and RNA-seq analyses. K.L.L., S.A.L. and P.T.E. supervised the overall study. S.H.C., S.J.J. and P.T.E. wrote the manuscript. All authors critically revised and approved the manuscript.