Dr Mohammed Enayat, a 41-year-old primary care doctor based in London, claims that his biological age is just 24 — 17 years younger than his chronological age.
The founder of the longevity-focused Hum2n clinic says he’s been tracking his health for seven years using wearables, along with frequent blood, urine, and microbiome testing. “While I believe these supplements have supported my biological age reversal, I credit them as one component in a much broader framework,” Dr Enayat told Business Insider, pointing to daily doses of “core” supplements such as vitamin B complex with folate, magnesium, and omega-3 fatty acids as part of his routine.
Dr Enayat said he takes vitamin B complex and folate due to a methylation gene defect that causes elevated homocysteine levels, which raises the risk of heart attack and stroke. “Even without a methylation-related gene defect, I would still consider taking a methylated B complex, particularly during periods of high stress, poor sleep, or intensive training, as these increase the demand for B vitamins,” he added.
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On magnesium, he opts for bisglycinate due to better absorption, reporting reduced muscle aches and better sleep. For omega-3 fatty acids, he supplements due to low levels and notes their potential anti-ageing and anti-inflammatory effects. Indianexpress.com speaks to an expert to verify the efficacy.
How reliable are biological age tests, and should the average person use them to guide their health decisions?
Dr Jagadish Hiremath, public health intellectual, says, “Biological age tests such as GlycanAge and TruAge PACE can offer some insight into the impact of lifestyle, stress, and inflammation on the body’s physiological state. These tests generally evaluate biomarkers correlating with cellular ageing or immune function, which differs from traditional diagnostics.”
However, he adds that while the science behind these tools is evolving, they are not yet universally standardised across populations. Their interpretation requires nuance and should not be viewed as standalone indicators of health or risk. “For the average person, these tests can serve as a supplementary checkpoint, but health decisions should still be grounded in regular clinical assessments and evidence-based screenings,” states Dr Hiremath.
Using a methylated B complex supplement, even without deficiency
Methylated B vitamins are more bioavailable forms, Dr Hiremath informs, particularly helpful for individuals with genetic variations such as MTHFR polymorphisms. “For those without such variants or a clinically diagnosed deficiency, taking a B complex occasionally during periods of high stress is unlikely to be harmful, but over-supplementation is unnecessary and may cause side effects in some cases, such as headaches or gastrointestinal upset,” he explains.
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The key is mindful dosing and timing. Vitamins should support a balanced diet, not replace it. If someone is considering supplements during stressful periods, a conversation with a healthcare provider can ensure the approach is both safe and targeted.
Given the growing trend of taking magnesium and omega-3s for sleep, muscle recovery, and anti-ageing, how can one determine whether supplements are necessary?
Dr Hiremath says, “Magnesium and omega-3 fatty acids are among the most researched and commonly used supplements with benefits ranging from cardiovascular health to sleep support. However, their necessity should ideally be determined by assessing dietary intake, lifestyle habits, and individual health needs.”
Blood tests can identify deficiencies, but even in their absence, some individuals, such as those with sleep issues or limited fish intake, might benefit from short-term supplementation. The goal should always be to supplement if needed, not as a blanket solution for everyone.
Finally, Dr Hiremath asserts, “Supplements can play a supportive role, but they are just one piece of the puzzle. A complex interplay of factors, including genetics, nutrition, physical activity, sleep, stress management, and social connection influences longevity.”
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DISCLAIMER: This article is based on information from the public domain and/or the experts we spoke to. Always consult your health practitioner before starting any routine.